NATIONAL TOXICOLOGY PROGRAM

Science you can depend on for decisions that matter.

The National Toxicology Program provides the scientific basis for programs, activities, and policies that promote health or lead to the prevention of disease. Founded in 1978, NTP plays a critical role in generating, interpreting, and sharing toxicological information about potentially hazardous substances in our environment. NTP strives to remain at the cutting edge of scientific research and the development and application of new technologies for modern toxicology and molecular biology.

A world leader in toxicology research, NTP has evaluated more than 2800 environmental substances for potential human health effects.

NTP technical report on the toxicology and carcinogenesis studies of beta-myrcene (CAS No. 123-35-3) in F344/N rats and B6C3F1 mice (Gavage studies) 'Conclusions: Under the conditions of these 2-year gavage studies, there was clear evidence of carcinogenic activity of beta-myrcene in male F344/N rats based on increased incidences of renal tubule neoplasms. There was equivocal evidence of carcinogenic activity of beta-myrcene in female F344/N rats based on increased incidences of renal tubule adenoma. There was clear evidence of carcinogenic activity of beta-myrcene in male B6C3F1 mice based on increased incidences of hepatocellular adenoma, hepatocellular carcinoma, and hepatoblastoma. There was equivocal evidence of carcinogenic activity of beta-myrcene in female B6C3F1 mice based on marginally increased incidences of hepatocellular adenoma and carcinoma. Administration of beta-myrcene induced nonneoplastic lesions in the kidney of male and female rats, nose of male rats, and liver of male and female mice.'